Frequency-specific neuromodulation of local and distant
Por um escritor misterioso
Last updated 24 outubro 2024
A growing literature has focused on the brain’s ability to augment processing in local regions by recruiting distant communities of neurons in response to neural decline or insult. In particular, both younger and older adult populations recruit bilateral prefrontal cortex (PFC) as a means of compensating for increasing neural effort to maintain successful cognitive function. However, it remains unclear how local changes in neural activity affect the recruitment of this adaptive mechanism. To address this problem, we combined graph theoretical measures from functional MRI (fMRI) with diffusion weighted imaging (DWI) and repetitive transcranial magnetic stimulation (rTMS) in order to resolve a central hypothesis: how do aged brains flexibly adapt to local changes in cortical activity? Specifically, we applied neuromodulation to increase or decrease local activity in a cortical region supporting successful memory encoding (left dorsolateral prefrontal cortex or DLPFC) using 5Hz or 1Hz rTMS, respectively. We then assessed a region’s local within-module degree (WMD), or the distributed between-module degree (BMD) between distant cortical communities. We predicted that (1) local stimulation-related deficits may be counteracted by boosting BMD between bilateral PFC, and that this effect should be (2) positively correlated with structural connectivity. Both predictions were confirmed; 5Hz rTMS increased local success-related activity and local increases in PFC connectivity, while 1Hz rTMS decreases local activity and triggered a more distributed pattern of bilateral PFC connectivity to compensate for this local inhibitory effect. These results provide an integrated, causal explanation for the network interactions associated with successful memory encoding in older adults.
Table of Contents page: Brain Stimulation: Basic, Translational
Frequency-Dependent Action of Neuromodulation
Biohybrid nanointerfaces for neuromodulation - ScienceDirect
Brain Sciences, Free Full-Text
A: ISI-distance. Illustration of the local quantities used to
Biology, Free Full-Text
Frontiers Phase-locked closed-loop ultrasound stimulation
Noninvasive Manipulation of Ion Channels for Neuromodulation and
Functional changes in prefrontal cortex following frequency
Ectopic expression of a mechanosensitive channel confers
Current Issue Table of Contents: Brain Stimulation: Basic
JCM, Free Full-Text
Remote, brain region–specific control of choice behavior with
State-dependent and cell-type-specific spontaneous firing. (A) An
Recomendado para você
-
Optical challenge: A Sherlock Holmes-like mind can find the hidden potato in 11 seconds! - alro news24 outubro 2024
-
Brain Test 4 Levels 156, 157, 158, 159, 160 Answers24 outubro 2024
-
Brain Test Level 411 solução dos jogos #braintest #respostas24 outubro 2024
-
Brain Test Level 411 (NEW) Light up the birthday candles Answer24 outubro 2024
-
Kunci Jawaban Brain Test Level 411 412 413 414 415 416 417: Sang24 outubro 2024
-
EarthBound / Mother 3 Goodness.24 outubro 2024
-
braintest level 411|TikTok Search24 outubro 2024
-
Brain Test Level 411 Jawaban - Games For Cats24 outubro 2024
-
Liquid Sort Puzzle Water Color Game for Android - Download24 outubro 2024
-
Frontiers Exploring decision-making strategies in the Iowa24 outubro 2024
você pode gostar
-
Homem desmaia ao ser atingido com bola de sinuca no pescoço durante briga em Manaus24 outubro 2024
-
2Pcs Gadget Egg Yolk White Separator Holder Sieve Funny Divider24 outubro 2024
-
Trends Ouch! Chad Meme Design Incel Stronk Tough Guy Work Out Gym24 outubro 2024
-
I recently installed Assassin's Creed 3 remastered from FitGirl24 outubro 2024
-
Pin em Luluca24 outubro 2024
-
Google Fotos – Wikipédia, a enciclopédia livre24 outubro 2024
-
HBO anuncia app de House of the Dragon para criares o teu dragão24 outubro 2024
-
The Chosen Brasil on X: Amamos quando vão além de apenas assistir os episódios. O que mais já aprenderam? / X24 outubro 2024
-
Spider Solitaire 2 Suits 🕹️ Jogue no CrazyGames24 outubro 2024
-
Shahih Fiqih - 📎 DOA MEMOHON AMPUN ATAS BANYAKNYA DOZA DAN24 outubro 2024