Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments
Por um escritor misterioso
Last updated 26 outubro 2024
The treatment of glioblastoma is challenging for the clinician, due to its chemotherapeutic resistance. Recent findings suggest that targeting glioblastoma using anti-cancer natural polyphenols is a promising strategy. In this context, curcumin and berberine have been shown to have potent anti-cancer and anti-inflammatory effects against several malignancies. Due to the poor solubility and limited bioavailability, these compounds have limited efficacy for treating cancer. However, use of a formulation of curcumin with higher bioavailability or combining it with berberine as a co-treatment may be proving to be more efficacious against cancer. Recently, we demonstrated that solid lipid curcumin particles (SLCPs) provided more bioavailability and anti-cancer effects in cultured glioblastoma cells than did natural curcumin. Interestingly, a combination of curcumin and berberine has proven to be more effective in inhibiting growth and proliferation of cancer in the liver, breast, lung, bone and blood. However, the effect of combining these drugs for treating glioblastoma, especially with respect to its effect on activating the PI3K/Akt/mTOR pathways has not been studied. Therefore, we decided to assess the co-treatment effects of these drugs on two different glioblastoma cell lines (U-87MG and U-251MG) and neuroblastoma cell lines (SH-SY5Y) derived from human tissue. In this study, we compared single and combination (1:5) treatment of SLCP (20 μM) and berberine (100 μM) on measures of cell viability, cell death markers, levels of c-Myc and p53, along with biomarkers of the PI3K/Akt/mTOR pathways after 24–48 h of incubation. We found that co-treatment of SLCP and berberine produced more glioblastoma cell death, more DNA fragmentation, and significantly decreased ATP levels and reduced mitochondrial membrane potential than did single treatments in both glioblastoma cells lines. In addition, we observed that co-treatment inhibited the PI3K/Akt/mTOR pathway more efficiently than their single treatments. Our study suggests that combination treatments of SLCP and berberine may be a promising strategy to reduce or prevent glioblastoma growth in comparison to individual treatments using either compound.
IJMS, Free Full-Text
Curcumin induces apoptosis and inhibits the growth of adrenocortical carcinoma: Identification of potential candidate genes and pathways by transcriptome analysis
PDF] Solid Lipid Curcumin Particles Induce More DNA Fragmentation and Cell Death in Cultured Human Glioblastoma Cells than Does Natural Curcumin
IJMS, Free Full-Text
Mixed Nanoscale Liposomes Co-Encapsulating Curcumin and Berberine Inhibit Activated Hepatic Stellate Cell-Induced Drug Resistance and Tumor Metastasis
Molecules, Free Full-Text
IJMS, Free Full-Text
PDF) Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments
Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
Frontiers Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer
Beta-Blockers and Berberine: A Possible Dual Approach to Contrast Neuroblastoma Growth and Progression
IJMS, Free Full-Text
Phytotherapy Research, Medicinal Chemistry Journal
Frontiers Therapeutic Potential of Autophagy in Glioblastoma Treatment With Phosphoinositide 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway Inhibitors
Recomendado para você
-
Jean-Nicolas Senzig - Mentor - Navy Federal Credit Union26 outubro 2024
-
CYELEE Wolf Pro… #cyeleewolfpro #pistolsights #rmr26 outubro 2024
-
A Study of Salvaged Cyanobacteria Slurry Treatment Using Liquefied Dimethyl Ether: Dehydration and Organic Matter Extraction26 outubro 2024
-
PDF) Вестник 11 2020 Кориневский26 outubro 2024
-
Apartamento para Alugar em Ponta Grossa, Contorno - Ref 424037-5 - Procure Imóvel26 outubro 2024
-
Image 11 of The sun (New York [N.Y.]), September 26, 190126 outubro 2024
-
KYMETA UNIVERSAL MOUNTING PLATE26 outubro 2024
-
CompactPCI and AdvancedTCA Systems - OpenSystems Media26 outubro 2024
-
Thraumata, a new genus from South America with description of a26 outubro 2024
-
A comprehensive review on peptide-bearing biomaterials: From ex situ to in situ self-assembly - ScienceDirect26 outubro 2024
você pode gostar
-
Hot off the Press: West Ham26 outubro 2024
-
Cabelo Bio Vegetal - Fashion Classic - Iza26 outubro 2024
-
Santi Maratea propuso organizar una colecta para pagar la deuda del Club Atlético Independiente - MMX26 outubro 2024
-
Regras e detalhes dos diferentes modos de jogo do Garena Free Fire26 outubro 2024
-
Análise: Farming Simulator 1826 outubro 2024
-
Decisivo contra o Galo, Weverton chega a 12 pênaltis defendidos pelo Verdão; veja lista – Palmeiras26 outubro 2024
-
CFEE52 - Guitar Hero III Custom : Michael Jackson26 outubro 2024
-
Kirby's Avalanche (SNESDG-V) Super Nintendo26 outubro 2024
-
Roblox BEAR*- idiot.bear Minecraft Skin26 outubro 2024
-
Konosuba - Kazuma Satou by Uniyou on DeviantArt26 outubro 2024